Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis.
Identifieur interne : 004690 ( Main/Exploration ); précédent : 004689; suivant : 004691Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis.
Auteurs : B C Ross [Australie] ; L. Czajkowski ; D. Hocking ; M. Margetts ; E. Webb ; L. Rothel ; M. Patterson ; C. Agius ; S. Camuglia ; E. Reynolds ; T. Littlejohn ; B. Gaeta ; A. Ng ; E S Kuczek ; J S Mattick ; D. Gearing ; I G BarrSource :
- Vaccine [ 0264-410X ] ; 2001.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Antigènes bactériens (immunologie), Données de séquences moléculaires (MeSH), Humains (MeSH), Lapins (MeSH), Porphyromonas gingivalis (génétique), Porphyromonas gingivalis (immunologie), Protéines de la membrane externe bactérienne (immunologie), Rat Sprague-Dawley (MeSH), Rats (MeSH), Souris (MeSH), Séquence d'acides aminés (MeSH), Technique de Western (MeSH), Vaccins antibactériens (immunologie), Vaccins synthétiques (immunologie).
- MESH :
- génétique : Porphyromonas gingivalis.
- immunologie : Antigènes bactériens, Porphyromonas gingivalis, Protéines de la membrane externe bactérienne, Vaccins antibactériens, Vaccins synthétiques.
- Animaux, Données de séquences moléculaires, Humains, Lapins, Rat Sprague-Dawley, Rats, Souris, Séquence d'acides aminés, Technique de Western.
English descriptors
- KwdEn :
- Amino Acid Sequence (MeSH), Animals (MeSH), Antigens, Bacterial (immunology), Bacterial Outer Membrane Proteins (immunology), Bacterial Vaccines (immunology), Blotting, Western (MeSH), Humans (MeSH), Mice (MeSH), Molecular Sequence Data (MeSH), Porphyromonas gingivalis (genetics), Porphyromonas gingivalis (immunology), Rabbits (MeSH), Rats (MeSH), Rats, Sprague-Dawley (MeSH), Vaccines, Synthetic (immunology).
- MESH :
- chemical , immunology : Antigens, Bacterial, Bacterial Outer Membrane Proteins, Bacterial Vaccines, Vaccines, Synthetic.
- genetics : Porphyromonas gingivalis.
- immunology : Porphyromonas gingivalis.
- Amino Acid Sequence, Animals, Blotting, Western, Humans, Mice, Molecular Sequence Data, Rabbits, Rats, Rats, Sprague-Dawley.
Abstract
Porphyromonas gingivalis is a key periodontal pathogen which has been implicated in the etiology of chronic adult periodontitis. Our aim was to develop a protein based vaccine for the prevention and or treatment of this disease. We used a whole genome sequencing approach to identify potential vaccine candidates. From a genomic sequence, we selected 120 genes using a series of bioinformatics methods. The selected genes were cloned for expression in Escherichia coli and screened with P. gingivalis antisera before purification and testing in an animal model. Two of these recombinant proteins (PG32 and PG33) demonstrated significant protection in the animal model, while a number were reactive with various antisera. This process allows the rapid identification of vaccine candidates from genomic data.
DOI: 10.1016/s0264-410x(01)00173-6
PubMed: 11457538
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis.</title><author><name sortKey="Ross, B C" sort="Ross, B C" uniqKey="Ross B" first="B C" last="Ross">B C Ross</name><affiliation wicri:level="1"><nlm:affiliation>Research and Development, CSL Ltd., 45 Poplar Road, Vic. 3052, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Research and Development, CSL Ltd., 45 Poplar Road, Vic. 3052, Parkville</wicri:regionArea><wicri:noRegion>Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Czajkowski, L" sort="Czajkowski, L" uniqKey="Czajkowski L" first="L" last="Czajkowski">L. Czajkowski</name></author><author><name sortKey="Hocking, D" sort="Hocking, D" uniqKey="Hocking D" first="D" last="Hocking">D. Hocking</name></author><author><name sortKey="Margetts, M" sort="Margetts, M" uniqKey="Margetts M" first="M" last="Margetts">M. Margetts</name></author><author><name sortKey="Webb, E" sort="Webb, E" uniqKey="Webb E" first="E" last="Webb">E. Webb</name></author><author><name sortKey="Rothel, L" sort="Rothel, L" uniqKey="Rothel L" first="L" last="Rothel">L. Rothel</name></author><author><name sortKey="Patterson, M" sort="Patterson, M" uniqKey="Patterson M" first="M" last="Patterson">M. Patterson</name></author><author><name sortKey="Agius, C" sort="Agius, C" uniqKey="Agius C" first="C" last="Agius">C. Agius</name></author><author><name sortKey="Camuglia, S" sort="Camuglia, S" uniqKey="Camuglia S" first="S" last="Camuglia">S. Camuglia</name></author><author><name sortKey="Reynolds, E" sort="Reynolds, E" uniqKey="Reynolds E" first="E" last="Reynolds">E. Reynolds</name></author><author><name sortKey="Littlejohn, T" sort="Littlejohn, T" uniqKey="Littlejohn T" first="T" last="Littlejohn">T. Littlejohn</name></author><author><name sortKey="Gaeta, B" sort="Gaeta, B" uniqKey="Gaeta B" first="B" last="Gaeta">B. Gaeta</name></author><author><name sortKey="Ng, A" sort="Ng, A" uniqKey="Ng A" first="A" last="Ng">A. Ng</name></author><author><name sortKey="Kuczek, E S" sort="Kuczek, E S" uniqKey="Kuczek E" first="E S" last="Kuczek">E S Kuczek</name></author><author><name sortKey="Mattick, J S" sort="Mattick, J S" uniqKey="Mattick J" first="J S" last="Mattick">J S Mattick</name></author><author><name sortKey="Gearing, D" sort="Gearing, D" uniqKey="Gearing D" first="D" last="Gearing">D. Gearing</name></author><author><name sortKey="Barr, I G" sort="Barr, I G" uniqKey="Barr I" first="I G" last="Barr">I G Barr</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11457538</idno><idno type="pmid">11457538</idno><idno type="doi">10.1016/s0264-410x(01)00173-6</idno><idno type="wicri:Area/Main/Corpus">004757</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">004757</idno><idno type="wicri:Area/Main/Curation">004757</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">004757</idno><idno type="wicri:Area/Main/Exploration">004757</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis.</title><author><name sortKey="Ross, B C" sort="Ross, B C" uniqKey="Ross B" first="B C" last="Ross">B C Ross</name><affiliation wicri:level="1"><nlm:affiliation>Research and Development, CSL Ltd., 45 Poplar Road, Vic. 3052, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Research and Development, CSL Ltd., 45 Poplar Road, Vic. 3052, Parkville</wicri:regionArea><wicri:noRegion>Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Czajkowski, L" sort="Czajkowski, L" uniqKey="Czajkowski L" first="L" last="Czajkowski">L. Czajkowski</name></author><author><name sortKey="Hocking, D" sort="Hocking, D" uniqKey="Hocking D" first="D" last="Hocking">D. Hocking</name></author><author><name sortKey="Margetts, M" sort="Margetts, M" uniqKey="Margetts M" first="M" last="Margetts">M. Margetts</name></author><author><name sortKey="Webb, E" sort="Webb, E" uniqKey="Webb E" first="E" last="Webb">E. Webb</name></author><author><name sortKey="Rothel, L" sort="Rothel, L" uniqKey="Rothel L" first="L" last="Rothel">L. Rothel</name></author><author><name sortKey="Patterson, M" sort="Patterson, M" uniqKey="Patterson M" first="M" last="Patterson">M. Patterson</name></author><author><name sortKey="Agius, C" sort="Agius, C" uniqKey="Agius C" first="C" last="Agius">C. Agius</name></author><author><name sortKey="Camuglia, S" sort="Camuglia, S" uniqKey="Camuglia S" first="S" last="Camuglia">S. Camuglia</name></author><author><name sortKey="Reynolds, E" sort="Reynolds, E" uniqKey="Reynolds E" first="E" last="Reynolds">E. Reynolds</name></author><author><name sortKey="Littlejohn, T" sort="Littlejohn, T" uniqKey="Littlejohn T" first="T" last="Littlejohn">T. Littlejohn</name></author><author><name sortKey="Gaeta, B" sort="Gaeta, B" uniqKey="Gaeta B" first="B" last="Gaeta">B. Gaeta</name></author><author><name sortKey="Ng, A" sort="Ng, A" uniqKey="Ng A" first="A" last="Ng">A. Ng</name></author><author><name sortKey="Kuczek, E S" sort="Kuczek, E S" uniqKey="Kuczek E" first="E S" last="Kuczek">E S Kuczek</name></author><author><name sortKey="Mattick, J S" sort="Mattick, J S" uniqKey="Mattick J" first="J S" last="Mattick">J S Mattick</name></author><author><name sortKey="Gearing, D" sort="Gearing, D" uniqKey="Gearing D" first="D" last="Gearing">D. Gearing</name></author><author><name sortKey="Barr, I G" sort="Barr, I G" uniqKey="Barr I" first="I G" last="Barr">I G Barr</name></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term><term>Animals (MeSH)</term><term>Antigens, Bacterial (immunology)</term><term>Bacterial Outer Membrane Proteins (immunology)</term><term>Bacterial Vaccines (immunology)</term><term>Blotting, Western (MeSH)</term><term>Humans (MeSH)</term><term>Mice (MeSH)</term><term>Molecular Sequence Data (MeSH)</term><term>Porphyromonas gingivalis (genetics)</term><term>Porphyromonas gingivalis (immunology)</term><term>Rabbits (MeSH)</term><term>Rats (MeSH)</term><term>Rats, Sprague-Dawley (MeSH)</term><term>Vaccines, Synthetic (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Antigènes bactériens (immunologie)</term><term>Données de séquences moléculaires (MeSH)</term><term>Humains (MeSH)</term><term>Lapins (MeSH)</term><term>Porphyromonas gingivalis (génétique)</term><term>Porphyromonas gingivalis (immunologie)</term><term>Protéines de la membrane externe bactérienne (immunologie)</term><term>Rat Sprague-Dawley (MeSH)</term><term>Rats (MeSH)</term><term>Souris (MeSH)</term><term>Séquence d'acides aminés (MeSH)</term><term>Technique de Western (MeSH)</term><term>Vaccins antibactériens (immunologie)</term><term>Vaccins synthétiques (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Bacterial</term><term>Bacterial Outer Membrane Proteins</term><term>Bacterial Vaccines</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Porphyromonas gingivalis</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Porphyromonas gingivalis</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes bactériens</term><term>Porphyromonas gingivalis</term><term>Protéines de la membrane externe bactérienne</term><term>Vaccins antibactériens</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Porphyromonas gingivalis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Blotting, Western</term><term>Humans</term><term>Mice</term><term>Molecular Sequence Data</term><term>Rabbits</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Lapins</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Souris</term><term>Séquence d'acides aminés</term><term>Technique de Western</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Porphyromonas gingivalis is a key periodontal pathogen which has been implicated in the etiology of chronic adult periodontitis. Our aim was to develop a protein based vaccine for the prevention and or treatment of this disease. We used a whole genome sequencing approach to identify potential vaccine candidates. From a genomic sequence, we selected 120 genes using a series of bioinformatics methods. The selected genes were cloned for expression in Escherichia coli and screened with P. gingivalis antisera before purification and testing in an animal model. Two of these recombinant proteins (PG32 and PG33) demonstrated significant protection in the animal model, while a number were reactive with various antisera. This process allows the rapid identification of vaccine candidates from genomic data.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11457538</PMID><DateCompleted><Year>2001</Year><Month>09</Month><Day>27</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>28</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0264-410X</ISSN><JournalIssue CitedMedium="Print"><Volume>19</Volume><Issue>30</Issue><PubDate><Year>2001</Year><Month>Jul</Month><Day>20</Day></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis.</ArticleTitle><Pagination><MedlinePgn>4135-42</MedlinePgn></Pagination><Abstract><AbstractText>Porphyromonas gingivalis is a key periodontal pathogen which has been implicated in the etiology of chronic adult periodontitis. Our aim was to develop a protein based vaccine for the prevention and or treatment of this disease. We used a whole genome sequencing approach to identify potential vaccine candidates. From a genomic sequence, we selected 120 genes using a series of bioinformatics methods. The selected genes were cloned for expression in Escherichia coli and screened with P. gingivalis antisera before purification and testing in an animal model. Two of these recombinant proteins (PG32 and PG33) demonstrated significant protection in the animal model, while a number were reactive with various antisera. This process allows the rapid identification of vaccine candidates from genomic data.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ross</LastName><ForeName>B C</ForeName><Initials>BC</Initials><AffiliationInfo><Affiliation>Research and Development, CSL Ltd., 45 Poplar Road, Vic. 3052, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Czajkowski</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Hocking</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Margetts</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Webb</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Rothel</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Patterson</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Agius</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Camuglia</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Reynolds</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Littlejohn</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Gaeta</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Kuczek</LastName><ForeName>E S</ForeName><Initials>ES</Initials></Author><Author ValidYN="Y"><LastName>Mattick</LastName><ForeName>J S</ForeName><Initials>JS</Initials></Author><Author ValidYN="Y"><LastName>Gearing</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Barr</LastName><ForeName>I G</ForeName><Initials>IG</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vaccine</MedlineTA><NlmUniqueID>8406899</NlmUniqueID><ISSNLinking>0264-410X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000942">Antigens, Bacterial</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001425">Bacterial Outer Membrane Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001428">Bacterial Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014614">Vaccines, Synthetic</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000942" MajorTopicYN="N">Antigens, Bacterial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001425" MajorTopicYN="N">Bacterial Outer Membrane Proteins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001428" MajorTopicYN="N">Bacterial Vaccines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016966" MajorTopicYN="N">Porphyromonas gingivalis</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011817" MajorTopicYN="N">Rabbits</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014614" MajorTopicYN="N">Vaccines, Synthetic</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>7</Month><Day>18</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>9</Month><Day>28</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>7</Month><Day>18</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11457538</ArticleId><ArticleId IdType="pii">S0264-410X(01)00173-6</ArticleId><ArticleId IdType="doi">10.1016/s0264-410x(01)00173-6</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Agius, C" sort="Agius, C" uniqKey="Agius C" first="C" last="Agius">C. Agius</name><name sortKey="Barr, I G" sort="Barr, I G" uniqKey="Barr I" first="I G" last="Barr">I G Barr</name><name sortKey="Camuglia, S" sort="Camuglia, S" uniqKey="Camuglia S" first="S" last="Camuglia">S. Camuglia</name><name sortKey="Czajkowski, L" sort="Czajkowski, L" uniqKey="Czajkowski L" first="L" last="Czajkowski">L. Czajkowski</name><name sortKey="Gaeta, B" sort="Gaeta, B" uniqKey="Gaeta B" first="B" last="Gaeta">B. Gaeta</name><name sortKey="Gearing, D" sort="Gearing, D" uniqKey="Gearing D" first="D" last="Gearing">D. Gearing</name><name sortKey="Hocking, D" sort="Hocking, D" uniqKey="Hocking D" first="D" last="Hocking">D. Hocking</name><name sortKey="Kuczek, E S" sort="Kuczek, E S" uniqKey="Kuczek E" first="E S" last="Kuczek">E S Kuczek</name><name sortKey="Littlejohn, T" sort="Littlejohn, T" uniqKey="Littlejohn T" first="T" last="Littlejohn">T. Littlejohn</name><name sortKey="Margetts, M" sort="Margetts, M" uniqKey="Margetts M" first="M" last="Margetts">M. Margetts</name><name sortKey="Mattick, J S" sort="Mattick, J S" uniqKey="Mattick J" first="J S" last="Mattick">J S Mattick</name><name sortKey="Ng, A" sort="Ng, A" uniqKey="Ng A" first="A" last="Ng">A. Ng</name><name sortKey="Patterson, M" sort="Patterson, M" uniqKey="Patterson M" first="M" last="Patterson">M. Patterson</name><name sortKey="Reynolds, E" sort="Reynolds, E" uniqKey="Reynolds E" first="E" last="Reynolds">E. Reynolds</name><name sortKey="Rothel, L" sort="Rothel, L" uniqKey="Rothel L" first="L" last="Rothel">L. Rothel</name><name sortKey="Webb, E" sort="Webb, E" uniqKey="Webb E" first="E" last="Webb">E. Webb</name></noCountry><country name="Australie"><noRegion><name sortKey="Ross, B C" sort="Ross, B C" uniqKey="Ross B" first="B C" last="Ross">B C Ross</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PoplarV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004690 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004690 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= PoplarV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:11457538
|texte= Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:11457538" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PoplarV1
| This area was generated with Dilib version V0.6.37. |  |